Biologics
| Peer-reviewed publication
Temperature control of growth and productivity in mutant Chinese hamster ovary cells synthesizing a recombinant protein
...was used at 39 degrees C to select mutagenized CHO-K1 cells, which resulted in the isolation of 31 temperature-sensitive mutants that were growth inhibited a...
https://www.lonza.com/knowledge-center/biologics/pub/temperature-control-of-growth-and-productivity